Search Result

Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

receptor protein tyrosine phosphatase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphatase (9) SHP2 (1) 5-HT Receptor (2) Biochemical Assay Reagents (2) Monoamine Oxidase (2)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Neurological Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Phosphatase Btk Syk PTEN DYRK SHP2 Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123856

MY10	Phosphatase	Neurological Disease
MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 attenuates binge-like ethanol consumption and ethanol reward .

HY-115496

7-BIA

1 Publications Verification

Phosphatase Neurological Disease

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC₅₀ of ~1-3 μM .

7-BIA 1 Publications Verification	Phosphatase	Neurological Disease
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC₅₀ of ~1-3 μM .

HY-P0320

EGF Receptor Substrate 2 (Phospho-Tyr5)	Phosphatase	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-P0320A

EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-P0320B

EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

HY-130631

SHP2-IN-5	SHP2	Cancer
SHP2-IN-5 (compound 1) is an inhibitor of SHP2 (IC₅₀: 97 nM). SHP2 is a non-receptor protein tyrosine phosphatase associated with cell growth and proliferation. SHP2-IN-5 has the potential to inhibit cancer and SHP2-related human diseases .

HY-124591

TC-2153	5-HT Receptor Monoamine Oxidase	Neurological Disease
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling .

HY-123966

MY33-3	Phosphatase
MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC₅₀ ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction .

HY-123966A

MY33-3 hydrochloride	Phosphatase	Neurological Disease
MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC₅₀ ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction .

HY-103693

NAZ2329 1 Publications Verification	Phosphatase	Cancer
NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC₅₀=7.5 µM for hPTPRZ1) and PTPRG (IC₅₀=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC₅₀ of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC₅₀ of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties .

EGF Receptor Substrate 2 (Phospho-Tyr5)	Phosphatase	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

Cassiaside B2	Monophenols Classification of Application Fields Cassia obtusifolia L. Source classification Phenols Caesalpiniaceae Plants Disease Research Fields Inflammation/Immunology	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

Species:	Human (24) Mouse (7)
Tag:	His (24) Tag Free (4) GST (6) Fc (3)
Source:	HEK293 (12) Sf9 insect cells (10) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P71141

	SHP-1 Protein, Human (His) tyrosine-protein phosphatase Non-receptor Type 6; Hematopoietic Cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1; PTPN6; HCP; PTP1C	Human	E. coli
	SHP-1 Protein modulates signaling from tyrosine-phosphorylated cell surface receptors, including KIT and EGFR. It enhances the inhibition of mast cell activation via the Lilrb4a receptor. The SH2 regions interact with cellular components to regulate its phosphatase activity. In collaboration with MTUS1, it induces UBE2V2 expression upon angiotensin II stimulation. SHP-1 plays a crucial role in hematopoiesis. SHP-1 Protein, Human (His) is the recombinant human-derived SHP-1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of SHP-1 Protein, Human (His) is 299 a.a., with molecular weight of ~33.0 kDa.

HY-P701970

	PTPRG Protein, Human PTPRG; receptor-type tyrosine-protein phosphatase gamma; protein-tyrosine phosphatase gamma; R-PTP-gamma	Human	E. coli
	PTPRG protein, also known as G-type protein tyrosine phosphatase receptor, is characterized by its tyrosine phosphatase activity. As a member of the protein tyrosine phosphatase (PTP) family, PTPRG is involved in the dephosphorylation of tyrosine residues in target proteins. PTPRG Protein, Human is the recombinant human-derived PTPRG protein, expressed by E. coli , with tag free. The total length of PTPRG Protein, Human is 311 a.a., .

HY-P701971

	PTPRG Protein, Human (His) PTPRG; receptor-type tyrosine-protein phosphatase gamma; protein-tyrosine phosphatase gamma; R-PTP-gamma	Human	E. coli
	PTPRG protein, also known as G-type protein tyrosine phosphatase receptor, is characterized by its tyrosine phosphatase activity. As a member of the protein tyrosine phosphatase (PTP) family, PTPRG is involved in the dephosphorylation of tyrosine residues in target proteins. PTPRG Protein, Human (His) is the recombinant human-derived PTPRG protein, expressed by E. coli , with N-6*His labeled tag. The total length of PTPRG Protein, Human (His) is 311 a.a., .

HY-P7884

	CD45 Protein, Mouse (HEK293, His) rMureceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C	Mouse	HEK293
	CD45/PTPRC Protein, Mouse (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. CD45 is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes. PTPRC is an essential regulator of T and B cell antigen receptor-mediated activation.

HY-P7887

	CD45 Protein, Human (552a.a, HEK293, His) rHureceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C	Human	HEK293
	CD45 Protein, Human (HEK 293, His) is a type 1 transmembrane protein tyrosine phosphatase (PTPase) expressed by all the haematopoietic stem cells (HSCs) except that of erythrocytes and platelets.

HY-P7889

	PTPRC/CD45RA Protein, Human (HEK293, His) rHureceptor-type tyrosine-protein phosphatase C/CD45RA, His ; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C	Human	HEK293
	Receptor-type tyrosine-protein phosphatase C (PTPRC) is a receptor type PTP and an essential positive regulator of T- and B-cell antigen receptor signaling. PTPRC functions through direct interaction with antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases as a regulator of cytokine receptor signaling. PTPRC/CD45RA Protein, Human (HEK293, His) is the recombinant human-derived PTPRC/CD45RA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7887A

	CD45 Protein, Human (552a.a, HEK293, C-His) rHureceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C	Human	HEK293
	Receptor-type tyrosine-protein phosphatase C (PTPRC) is a receptor type PTP and an essential positive regulator of T- and B-cell antigen receptor signaling. PTPRC functions through direct interaction with antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases as a regulator of cytokine receptor signaling. CD45 Protein, Human (552a.a, HEK293, C-His) is the recombinant human-derived CD45 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD45 Protein, Human (552a.a, HEK293, C-His) is 552 a.a., with molecular weight (glycosylation form) of 130-180 kDa.

HY-P76557

	PTPN12 Protein, Human tyrosine-protein phosphatase non-receptor type 12; PTP-PEST; PTPG1	Human	Sf9 insect cells
	PTPN12 Protein, a versatile enzyme, dephosphorylates various proteins, regulating cellular signaling cascades. Documented in literature, PTPN12 selectively targets tyrosine kinases like ERBB2 and PTK2B/PYK2, exerting control over associated pathways. Notably, PTPN12's specificity is evident in dephosphorylating ERBB2 at specific tyrosine residues, such as 'Tyr-1112,' 'Tyr-1196,' and/or 'Tyr-1248.' Its intricate dephosphorylation activity underscores PTPN12's significance in modulating key signaling events and fine-tuning cellular responses within tyrosine kinase pathways. PTPN12 Protein, Human is the recombinant human-derived PTPN12 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of PTPN12 Protein, Human is 355 a.a., with molecular weight of ~41 kDa.

HY-P7888

	PTPRC/CD45R0 Protein, Human (HEK293, His) rHureceptor-type tyrosine-protein phosphatase C/ CD45R0, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C; CD45R0	Human	HEK293
	PTPRC/CD45R0 Protein, Human (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. CD45R0 (UCHL1), a member of leucocyte common antigen family, is expressed largely on previously activated or memory T cells.

HY-P700618

	SHP-2 Protein, Human (T253M, Q257L, His) protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433	Human	E. coli
	The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L, , , mutation. The total length of SHP-2 Protein, Human (T253M, Q257L, His) is 592 a.a., with molecular weight of 70-75 kDa.

HY-P76103

	TCPTP Protein, Human (sf9) tyrosine-protein phosphatase non-receptor type 2; TCPTP; PTPN2; PTPT	Human	Sf9 insect cells
	TCPTP, a non-receptor tyrosine-specific phosphatase, critically regulates various kinases (INSR, EGFR, JAKs, Src), influencing hematopoiesis, inflammation, cell proliferation, and glucose homeostasis. In the immune system, TCPTP modulates T-cell receptor signaling, inhibiting cytokine pathways (IL2, interferon). It negatively regulates EGF-stimulated cell growth, PDGF receptor-beta signaling, and insulin receptor signaling, impacting glucose homeostasis and liver glucose production through the IL6 pathway. TCPTP's broad influence emphasizes its pivotal role in diverse cellular processes. TCPTP Protein, Human (sf9) is the recombinant human-derived TCPTP protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of TCPTP Protein, Human (sf9) is 314 a.a., with molecular weight of ~37 kDa.

HY-P76669

	TCPTP Protein, Mouse (sf9, His) 4 Publications Verification tyrosine-protein phosphatase non-receptor type 2; MPTP; PTPN2	Mouse	Sf9 insect cells
	TCPTP is a non-receptor tyrosine-specific phosphatase that regulates multiple signaling pathways by dephosphorylating proteins such as INSR, EGFR, CSF1R, PDGFR, JAK, Src kinase and STAT. TCPTP acts in the nucleus and cytoplasm to regulate hematopoiesis, inflammation, cell proliferation, differentiation, and glucose homeostasis. TCPTP Protein, Mouse (sf9, His) is the recombinant mouse-derived TCPTP protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TCPTP Protein, Mouse (sf9, His) is 313 a.a., with molecular weight of ~42 kDa.

HY-P72914

	CD45 Protein, Mouse (sf9) receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45	Mouse	Sf9 insect cells
	CD45 Protein, a versatile member of the protein tyrosine phosphatase family, displays heparan sulfate proteoglycan and heparin binding activity, as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecule metabolic processes, and signal transduction regulation. CD45 is associated with diseases such as systemic lupus erythematosus, hepatitis C, multiple sclerosis, and severe combined immunodeficiency. CD45 Protein, Mouse (sf9) is the recombinant mouse-derived CD45 protein, expressed by Sf9 insect cells , with tag free. The total length of CD45 Protein, Mouse (sf9) is 700 a.a., with molecular weight of ~93 kDa.

HY-P72916

	CD45 Protein, Mouse (HEK293, Fc) receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45	Mouse	HEK293
	The CD45 protein is a multifunctional member of the protein tyrosine phosphatase family with heparan sulfate proteoglycan and heparin binding activity as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecular metabolic processes, and signal transduction regulation. CD45 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD45 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD45 Protein, Mouse (HEK293, Fc) is 400 a.a., with molecular weight of ~130 kDa.

HY-P73685

	PTP1B Protein, Human (His) PTP-1B; PTPN1; tyrosine-protein phosphatase non-receptor type 1	Human	E. coli
	PTP1B is an important tyrosine protein phosphatase that regulates the endoplasmic reticulum unfolded protein response by dephosphorylating EIF2AK3/PERK and inhibiting its kinase activity. It affects the signaling cascade induced by CKII and p60c-src, and may regulate the EFNA5-EPHA3 pathway, affecting cell reorganization. PTP1B Protein, Human (His) is the recombinant human-derived PTP1B protein, expressed by E. coli , with N-His labeled tag. The total length of PTP1B Protein, Human (His) is 320 a.a., with molecular weight of ~38.1 kDa.

HY-P76104

	TCPTP Protein, Human (sf9, His-GST) tyrosine-protein phosphatase non-receptor type 2; TCPTP; PTPN2; PTPT	Human	Sf9 insect cells
	TCPTP is a non-receptor tyrosine-specific phosphatase that critically regulates various kinases (INSR, EGFR, JAK, Src) affecting hematopoiesis, inflammation, cell proliferation, and glucose homeostasis. In the immune system, TCPTP regulates T cell receptor signaling and inhibits cytokine pathways (IL2, interferon). TCPTP Protein, Human (sf9, His-GST) is the recombinant human-derived TCPTP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of TCPTP Protein, Human (sf9, His-GST) is 314 a.a., with molecular weight of ~60 kDa.

HY-P72915

	CD45 Protein, Mouse (sf9, His-GST) receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45	Mouse	Sf9 insect cells
	CD45 Protein, a versatile member of the protein tyrosine phosphatase family, displays heparan sulfate proteoglycan and heparin binding activity, as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecule metabolic processes, and signal transduction regulation. CD45 is associated with diseases such as systemic lupus erythematosus, hepatitis C, multiple sclerosis, and severe combined immunodeficiency. CD45 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CD45 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CD45 Protein, Mouse (sf9, His-GST) is 700 a.a., with molecular weight of ~110 kDa.

HY-P76558

	PTPN12 Protein, Human (sf9, His-GST) tyrosine-protein phosphatase non-receptor type 12; PTP-PEST; PTPG1	Human	Sf9 insect cells
	The PTPN12 protein is a multifunctional enzyme that can dephosphorylate a variety of proteins and regulate cell signaling cascades. According to literature, PTPN12 selectively targets tyrosine kinases such as ERBB2 and PTK2B/PYK2 to control related pathways. PTPN12 Protein, Human (sf9, His-GST) is the recombinant human-derived PTPN12 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag. The total length of PTPN12 Protein, Human (sf9, His-GST) is 355 a.a., with molecular weight of ~64 kDa.

HY-P76555

	PTP alpha/PTPRA Protein, Human (sf9, His-GST) receptor-type tyrosine-protein phosphatase alpha; R-PTP-alpha; PTPA; PTPRL2	Human	Sf9 insect cells
	PTP alpha/PTPRA Protein, a tyrosine protein phosphatase, participates in integrin-mediated focal adhesion formation. Upon integrin engagement, it recruits BCAR3, BCAR1, and CRK to focal adhesions, promoting SRC-mediated phosphorylation of BRAC1. This leads to the activation of PAK and small GTPases RAC1 and CDC42. PTP alpha/PTPRA Protein, Human (sf9, His-GST) is the recombinant human-derived PTP alpha/PTPRA protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PTP alpha/PTPRA Protein, Human (sf9, His-GST) is 620 a.a., with molecular weight of ~90 kDa.

HY-P72913

	PTPRC/CD45R0 Protein, Human (HEK293, Fc) receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45	Human	HEK293
	Receptor-type tyrosine-protein phosphatase C (PTPRC) is a receptor type PTP and an essential positive regulator of T- and B-cell antigen receptor signaling. PTPRC functions through direct interaction with antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases as a regulator of cytokine receptor signaling. PTPRC/CD45R0 Protein, Human (HEK293, Fc) is the recombinant human-derived PTPRC/CD45R0 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PTPRC/CD45R0 Protein, Human (HEK293, Fc) is 416 a.a., with molecular weight of ~122 kDa.

HY-P74549

	SHP-2 Protein, Mouse (HEK293, His) tyrosine-protein phosphatase non-receptor type 11; SH-PTP2; SHP-2; Ptpn11	Mouse	HEK293
	SHP-2 Protein functions downstream of diverse receptor and cytoplasmic tyrosine kinases, participating in signal transduction from the cell surface to the nucleus. It positively regulates the MAPK pathway and dephosphorylates key proteins like GAB1, ARHGAP35, EGFR, ROCK2, CDC73, and SOX9. Additionally, SHP-2 dephosphorylates NEDD9/CAS-L to modulate cellular processes. SHP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SHP-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of SHP-2 Protein, Mouse (HEK293, His) is 593 a.a., with molecular weight of ~65 kDa.

HY-P74200

	DEP-1/CD148 Protein, Human (341a.a, His) receptor-type tyrosine-protein phosphatase eta; R-PTP-eta; DEP-1; CD148; PTPRJ	Human	E. coli
	DEP-1/CD148 protein is a tyrosine phosphatase that affects multiple targets such as CTNND1, FLT3, PDGFRB, and EGFR, thereby affecting cellular processes such as adhesion, migration, proliferation, and differentiation. DEP-1/CD148 is critical in vascular development, regulating macrophage adhesion, platelet activation, and thrombosis, while negatively regulating cell proliferation and PDGF-stimulated migration. DEP-1/CD148 Protein, Human (341a.a, His) is the recombinant human-derived DEP-1/CD148 protein, expressed by E. coli , with N-His labeled tag. The total length of DEP-1/CD148 Protein, Human (341a.a, His) is 341 a.a., with molecular weight of ~37 kDa.

HY-P74290

	PTPRC/CD45RAB Protein, Human (529a.a, HEK293, His) receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45	Human	HEK293
	Receptor-type tyrosine-protein phosphatase C (PTPRC) is a receptor type PTP and an essential positive regulator of T- and B-cell antigen receptor signaling. PTPRC functions through direct interaction with antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases as a regulator of cytokine receptor signaling. PTPRC/CD45RAB Protein, Human (529a.a, HEK293, His) is the recombinant human-derived PTPRC/CD45RAB protein, expressed by HEK293 , with C-His labeled tag. The total length of PTPRC/CD45RAB Protein, Human (529a.a, HEK293, His) is 529 a.a., with molecular weight of ~57.4 kDa.

HY-P77170

	PTP-MEG2/PTPN9 Protein, Human (sf9, His-GST) tyrosine-protein phosphatase non-receptor type 9; PTPase MEG2; PTPN9	Human	Sf9 insect cells
	The PTP-MEG2/PTPN9 protein is a multifunctional protein tyrosine phosphatase with potential roles related to hydrophobic ligand transfer or Golgi function. It operates in a complex cellular environment, demonstrating the versatility of different molecular processes. PTP-MEG2/PTPN9 Protein, Human (sf9, His-GST) is the recombinant human-derived PTP-MEG2/PTPN9 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of PTP-MEG2/PTPN9 Protein, Human (sf9, His-GST) is 309 a.a., with molecular weight of ~63.3 KDa.

HY-P73649

	SHP-1 Protein, Mouse (sf9, His-GST) tyrosine-protein phosphatase non-receptor type 6; 70Z-SHP; PTP-1C; SHP-1; Ptpn6	Mouse	Sf9 insect cells
	SHP-1 Protein modulates signaling from tyrosine-phosphorylated cell surface receptors, including KIT and EGFR. It enhances the inhibition of mast cell activation via the Lilrb4a receptor. The SH2 regions interact with cellular components to regulate its phosphatase activity. In collaboration with MTUS1, it induces UBE2V2 expression upon angiotensin II stimulation. SHP-1 plays a crucial role in hematopoiesis. SHP-1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived SHP-1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SHP-1 Protein, Mouse (sf9, His-GST) is 391 a.a., with molecular weight of ~63 kDa.

HY-P70484

	SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, His) tyrosine-protein phosphatase Non-receptor Type Substrate 1; SHP Substrate 1; SHPS-1; Brain Ig-Like Molecule with tyrosine-Based Activation Motifs; Bit; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion receptor; MyD-1 Antigen; Signa	Human	HEK293
	SIRP alpha/CD172a Protein, Human (CAA71403.1, HEK 293, His) , as a recombinant protein produced in HEK293 cells, is a polypeptide chain with a His tag.

HY-P70689

	SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, Fc) tyrosine-protein phosphatase Non-receptor Type Substrate 1; SHPS-1; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP	Human	HEK293
	SIRP alpha/CD172a Protein, Human (CAA71403.1, HEK 293, Fc) is a recombinant protein expressed in HEK 293 cells. SIRP alpha/CD172a Protein, Human (CAA71403.1, HEK 293, Fc) is expressed with the Fc region of mouse IgG2a at the C-terminus.

HY-P70847

	IA2 Protein, Human (293a.a, His) receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (293a.a, His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (293a.a, His) is 293 a.a., with molecular weight of ~34.86 kDa.

HY-P70848

	IA2 Protein, Human (365a.a, His) receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	IA2 Protein is pivotal in vesicle-mediated secretory processes, crucial for secretory vesicle accumulation in the hippocampus, pituitary, and pancreatic islets. Essential for insulin-related functions, IA2 ensures normal insulin-containing vesicle levels, preventing degradation and promoting glucose-stimulated insulin secretion. IA2's influence extends to neurotransmitter regulation, required for normal norepinephrine, dopamine, and serotonin accumulation. In females, IA2 is uniquely essential for pituitary hormone accumulation and secretion. It also maintains normal renin expression. Despite lacking intrinsic enzyme activity, IA2 may regulate active protein-tyrosine phosphatases, like PTPRA, through dimerization. IA2's interaction with ICA512-TMF highlights its role in modulating insulin secretory granule dynamics and proposes a tethering mechanism to the actin cytoskeleton, dependent on UTRN and regulated by ICA512-CFF dimerization. IA2 Protein, Human (365a.a, His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (365a.a, His) is 375 a.a., with molecular weight of 45-50 kDa.

HY-P70847A

	IA2 Protein, Human (293a.a, N-His) receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	IA2 Protein is pivotal in vesicle-mediated secretory processes, crucial for secretory vesicle accumulation in the hippocampus, pituitary, and pancreatic islets. Essential for insulin-related functions, IA2 ensures normal insulin-containing vesicle levels, preventing degradation and promoting glucose-stimulated insulin secretion. IA2's influence extends to neurotransmitter regulation, required for normal norepinephrine, dopamine, and serotonin accumulation. In females, IA2 is uniquely essential for pituitary hormone accumulation and secretion. It also maintains normal renin expression. Despite lacking intrinsic enzyme activity, IA2 may regulate active protein-tyrosine phosphatases, like PTPRA, through dimerization. IA2's interaction with ICA512-TMF highlights its role in modulating insulin secretory granule dynamics and proposes a tethering mechanism to the actin cytoskeleton, dependent on UTRN and regulated by ICA512-CFF dimerization. IA2 Protein, Human (293a.a, N-His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (293a.a, N-His) is 293 a.a., with molecular weight of ~35 kDa.

HY-P700427

	NRG1-beta 1 Protein, Human (HEK293, His) receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	HEK293
	NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (HEK293, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NRG1-beta 1 Protein, Human (HEK293, His) is 228 a.a., with molecular weight of 27.1 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81307

SHP1 Antibody (YA1044) PTPN6; HCP; PTP1C; tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1	WB, IP	Human

HY-P81307A

SHP1 Antibody (YA1045) PTPN6; HCP; PTP1C; tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1	WB, IHC-P	Human

HY-P82031

PTP1B Antibody (YA1776)

PTPN1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein-tyrosine phosphatase 1B; PTP-1B
WB, IHC-F, IHC-P, ICC/IF Human
HY-P81300

Phospho-PTP1B (Ser352) Antibody (YA1027)

PTPN1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein-tyrosine phosphatase 1B; PTP-1B
WB, ICC/IF, IP Human
HY-P81300A

Phospho-PTP1B (Ser378) Antibody (YA1028)

PTPN1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein-tyrosine phosphatase 1B; PTP-1B
WB, IHC-P Human

HY-P81898

SHP2 Antibody (YA1643) PTPN11; PTP2C; SHPTP2; tyrosine-protein phosphatase non-receptor type 11; protein-tyrosine phosphatase 1D; PTP-1D; protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3	WB, IHC-P, IP	Human

HY-P80603

CD45 Antibody (YA800) PTPRC; CD45; receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45	WB, IHC-P	Human, Mouse
CD45 Antibody (YA800) is a non-conjugated and Mouse origined monoclonal antibody about 147 kDa, targeting to CD45. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P81616

SIRP alpha Antibody (YA1361) SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibito	FC, ELISA	Human

HY-P80785

PGP9.5 Antibody UCHL1 / PGP9.5; UCHL1; B220; CD 45; CD45; cd45 antigen; ec3.1.3.48; GP 180; GP180; Human homolog of severe combined immunodeficiency due to PTPRC deficiency; L CA; L-CA; lca; Leukocyte common antigen; LY 5; LY5; protein tyrosine phosphatase receptor type	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
PGP9.5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 25 kDa, targeting to PGP9.5. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

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